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A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses→
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Wec AZ et al, Science 2016
Read MoreA Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles→
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Ndungo E et al, mSphere 2016
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Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway→
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Read MoreFilovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats→
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Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015
Read MoreHaploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion→
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Read MoreNiemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo→
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Herbert AS et al, MBio 2015
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A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner→
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Read MoreEndocytic pathways involved in filovirus entry: advances, implications and future directions→
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Read MoreNPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor→
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Ebola virus entry requires the host-programmed recognition of an intracellular receptor→
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Read MoreFiloviruses require endosomal cysteine proteases for entry but display distinct protease preferences→
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Misasi J, Chandran K et al, J Virol 2012
Read MoreThe Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway→
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Read MoreEbola virus entry requires the cholesterol transporter Niemann-Pick C1→
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