May 18, 2017

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability→

May 18, 2017/ Kartik Chandran

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Zhao X et al, Cell 2017

May 18, 2017

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses→

May 18, 2017/ Kartik Chandran

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec AZ et al, Cell 2017

September 08, 2016

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses→

September 08, 2016/ Kartik Chandran

A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

March 30, 2016

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles→

March 30, 2016/ Kartik Chandran

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

Ndungo E et al, mSphere 2016

February 23, 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies→

February 23, 2016/ Kartik Chandran

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

December 23, 2015

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats→

December 23, 2015/ Kartik Chandran

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015

May 26, 2015

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo→

May 26, 2015/ Kartik Chandran

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo

Herbert AS et al, MBio 2015

October 11, 2014

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1→

October 11, 2014/ Kartik Chandran

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Ng M et al, Virology 2014

January 09, 2013

A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner→

January 09, 2013/ Kartik Chandran

A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner

Martinez O et al, J Virol 2013

October 25, 2012

NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor→

October 25, 2012/ Kartik Chandran

NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Krishnan A et al, Viruses 2012

March 06, 2012

Ebola virus entry requires the host-programmed recognition of an intracellular receptor→

March 06, 2012/ Kartik Chandran

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Miller EH, Obernosterer G, Raaben M, Herbert AS et al, EMBO J 2012

August 24, 2011

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1→

August 24, 2011/ Kartik Chandran

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Carette JE, Raaben M, Wong AC et al, Nature 2011