Selected publications

(Click here for complete bibliography) 

FEATURED
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence JS et al, mBio 2016

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion
Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter LM, Jangra RK, Jae LT et al, MBio 2015

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo
Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo

Herbert AS et al, MBio 2015

Ebola virus entry requires the host-programmed recognition of an intracellular receptor
Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Miller EH, Obernosterer G, Raaben M, Herbert AS et al, EMBO J 2012

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Carette JE, Raaben M, Wong AC et al, Nature 2011

PROGRAMMED CELL DEATH
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Brojatsch J et al, Cell Cycle 2015

A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants
A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants

Jacobson J et al, PLoS One 2014

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

Lima H, Jacobson LS et al, Cell Cycle 2013

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants
Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

Jacobson LS et al, J Biol Chem 2013

Browse by year:

2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010

2016–2017
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses
A “Trojan horse” bispecific antibody strategy for broad protection against ebolaviruses

Wec AZ et al, Science 2016

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt ZA et al, mBio 2016

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence JS et al, mBio 2016

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses
Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Frei JC, Nyakatura EK, et al, Sci Rep 2016

Cysteine cathepsin inhibitors as anti-Ebola agents
Cysteine cathepsin inhibitors as anti-Ebola agents

van der Linden W et al, ACS Infect Dis 2016

2014–2015
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng M, Ndungo E, Kaczmarek ME et al, eLife 2015

Novel small molecule entry inhibitors of Ebola virus
Novel small molecule entry inhibitors of Ebola virus

Basu A et al, J Infect Dis 2015

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion
Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter LM, Jangra RK, Jae LT et al, MBio 2015

Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo
Niemann-Pick C1 Is essential for ebolavirus replication and pathogenesis in vivo

Herbert AS et al, MBio 2015

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Brojatsch J et al, Cell Cycle 2015

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1
Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Ng M et al, Virology 2014

Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge
Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge

Chen G, Koellhoffer JF, Zak SE et al, ACS Chem Biol 2014

A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants
A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants

Jacobson J et al, PLoS One 2014

Comprehensive functional analysis of N-linked glycans on Ebola virus GP1
Comprehensive functional analysis of N-linked glycans on Ebola virus GP1

Lennemann NJ et al, MBio 2014

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species
Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species

Koellhoffer JF, Dai Z et al, J Mol Biol 2014

2012–2013
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

Lima H, Jacobson LS et al, Cell Cycle 2013

Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids
Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids

Regula LK, Harris R et al, Biochemistry 2013

A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner
A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species and cell-type specific manner

Martinez O et al, J Virol 2013

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants
Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

Jacobson LS et al, J Biol Chem 2013

Endocytic pathways involved in filovirus entry: advances, implications and future directions
Endocytic pathways involved in filovirus entry: advances, implications and future directions

Bhattacharyya S et al, Viruses 2012

Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein
Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the Ebola virus envelope glycoprotein

Koellhoffer JF, Chen G et al, Chembiochem 2012

NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor
NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Krishnan A et al, Viruses 2012

Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation
Crystal Structure of the Marburg virus GP2 core domain in its post-fusion conformation

Koellhoffer JF et al, Biochemistry 2012

Structural basis for differential neutralization of ebolaviruses
Structural basis for differential neutralization of ebolaviruses

Bale S, Dias JM et al, Viruses 2012

Filovirus entry into cells—new insights
Filovirus entry into cells—new insights

Miller and Chandran, Curr Opin Virol 2012

2010–2011
A shared immunological solution for neutralization of ebolaviruses
A shared immunological solution for neutralization of ebolaviruses

Dias JM et al, Nat Struct Mol Biol 2011

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway
The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

Mulherkar N et al, Virology 2011

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection
Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

Côté M, Misasi J, Ren T, Bruchez A et al, Nature 2011

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Carette JE, Raaben M, Wong AC et al, Nature 2011

Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects
Designed protein mimics of the Ebola virus glycoprotein GP2 alpha-helical bundle: Stability and pH effects

Harrison JS, Higgins CD et al, Protein Sci 2011

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes
Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

Miller EH, Harrison JS et al, J Biol Chem 2011

Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles
Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles

Martinez O et al, J Infect Dis 2011

A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry
A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry

Wong AC et al, J Virol 2010